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Stroke-like episodes: cardinal feature of MELAS

Neurological signs:

  • Hemiparesis
  • Hemianopia
  • Cortical blindess
  • Focal and generalized seizures
  • Dementia
  • Reccurent migrainelike headaches
  • Muscle weakness

Systemic manifestations:

  • Short stature
  • Hearing loss
  • Recurrent vomiting
  • Diabetes mellitus