World Stroke Organization #MondayTips
Every Monday, WSA Social Media Leader Rodrigo Guerrero publishes a #MondayTip on the WSA WorldStrokeEd Twitter account, covering a specific stroke related topic. You can find a compilation of our #MondayTips here!
#MondayTip
#Tenecteplase may help—even when the artery stays closed.
In #TRACE3 (4.5–24h window), pts without recanalization still had better outcomes (42% vs 30%). Strongest effect in NIHSS ≥10.
👉 Think beyond large vessel reopening
https://doi.org/10.1186/s12916-026-04877-x
#MondayTip
Can we prevent stroke without increasing bleeding?
Factor XIa inhibition #asundexian :
🔹⬇️recurrent stroke (HR 0.74)
🔸with no ⬆️major bleeding in OCEANIC-STROKE.
A potential shift in secondary prevention. 🧠⚖️
🔗 https://www.nejm.org/doi/full/10.1056/NEJMoa2513880
#MondayTip
#GFAP
📈Rises early in intracerebral hemorrhage (2–6h)🩸, but later in ischemic stroke (peak days 2–5)
💡Promising for early differentiation & triage
☝️but not ready as a standalone test
https://doi.org/10.3390/jcm14217748
#MondayTip
#Collaterals
Collateral status are relevant in stroke
🧠 Good collaterals + recanalization → strong outcomes
⚠️ Poor collaterals → limited benefit, even if opened
CTA isn’t just diagnostic—it’s decision-making
https://doi.org/10.3174/ajnr.a3817
#MondayTip
Cancer-related stroke ≠ routine ESUS
~50% of strokes in active cancer are cryptogenic, but many are cancer-driven hypercoagulable events
🔁14–29% recur at 1 year
⚖️Anticoag vs aspirin? Still equipoise
🧠Classify. Risk-stratify. Individualize
https://doi.org/10.1161/str.0000000000000517
#MondayTip
Hypoperfusion Intensity Ratio
#HIR may be the most practical collateral biomarker in AIS
⬆️High HIR (>0.4) → rapid core growth, ↑ hemorrhage risk, worse mRS.
⬇️Low HIR → robust collaterals & better EVT outcomes.
https://doi.org/10.3174/ajnr.A8557
Missed what happened in February at @WorldStrokeEd? 👀
Catch up with our monthly newsletter!
🎓 Upcoming & past webinars
🎙️ New podcast episodes
📊 Fresh infographics
💡 Latest #MondayTips by @interneurona
🤓 Read it here:
https://www.world-stroke-academy.org/news/february-newsletter-3/
#StrokeEducation #StrokeCare
#MondayTip
Not all “seizures” are epilepsy.
🧠 #LimbShakingTIA = hypoperfusion from carotid disease
📌 Triggered by standing/exertion
📉 EEG often normal
⚠️ Treat flow, not firing
https://doi.org/10.1136/pn-2025-004976
#MondayTip
New AHA dyslipidemia guides emphasizes earlier &➕ intensive LDL-C⬇️, often requiring non-statin therapy
PCSK9 options:
🧬Inclisiran (siRNA):↓PCSK9 production, dosing every 6m
💉Alirocumab/Evolocumab:✋circulating PCSK9
Both ↓LDL~50–60%, including in stroke patients
Missed what happened in February at @WorldStrokeEd? 👀
Catch up with our monthly newsletter!
🎓 Upcoming & past webinars
🎙️ New podcast episodes
📊 Fresh infographics
💡 Latest #MondayTips by @interneurona
🤓 Read it here:
https://www.world-stroke-academy.org/news/february-newsletter-3/
#StrokeEducation #StrokeCare
#MondayTip
#Stroke is not the same in #women and men
☝️Women have unique risk factors (pregnancy complications, menopause), are more likely to be misdiagnosed, rec&eive thrombolysis less often, despite similar benefit
Time for sex-responsive stroke care
https://doi.org/10.1177/17474930251393009
#MondayTip
Hypoperfusion Intensity Ratio
#HIR may be the most practical collateral biomarker in AIS
⬆️High HIR (>0.4) → rapid core growth, ↑ hemorrhage risk, worse mRS.
⬇️Low HIR → robust collaterals & better EVT outcomes.
https://doi.org/10.3174/ajnr.A8557
#MondayTip
Cancer-related stroke ≠ routine ESUS
~50% of strokes in active cancer are cryptogenic, but many are cancer-driven hypercoagulable events
🔁14–29% recur at 1 year
⚖️Anticoag vs aspirin? Still equipoise
🧠Classify. Risk-stratify. Individualize
https://doi.org/10.1161/str.0000000000000517
#MondayTip
Cancer-related stroke ≠ routine ESUS
~50% of strokes in active cancer are cryptogenic, but many are cancer-driven hypercoagulable events
🔁14–29% recur at 1 year
⚖️Anticoag vs aspirin? Still equipoise
🧠Classify. Risk-stratify. Individualize
https://doi.org/10.1161/str.0000000000000517
#MondayTIP
#FLAIR hyperintense vessels ≠ clot
🧩Hemodynamic clue!
🧠Distal FVH→collateral flow
⏱ Early window→possible viable penumbra
⚠️In TIA→ think persistent large-vessel stenosis
☝️Sometimes FLAIR tells you what perfusion can’t
🔎Look closely
https://bit.ly/4rntsAA
#MondayTip
#Tenecteplase may help—even when the artery stays closed.
In #TRACE3 (4.5–24h window), pts without recanalization still had better outcomes (42% vs 30%). Strongest effect in NIHSS ≥10.
👉 Think beyond large vessel reopening
https://doi.org/10.1186/s12916-026-04877-x
🎙️In the final episode of our Spasticity Unlocked series we shift the focus to what matters most: 𝐭𝐡𝐞 𝐩𝐚𝐭𝐢𝐞𝐧𝐭.
Dr. Stevens is joined by Gerard Sewell, offering a powerful & personal perspective on navigating life with #spasticity.
🔢Episodes: https://shorturl.at/F2QYE
#MondayTip
Can we prevent stroke without increasing bleeding?
Factor XIa inhibition #asundexian :
🔹⬇️recurrent stroke (HR 0.74)
🔸with no ⬆️major bleeding in OCEANIC-STROKE.
A potential shift in secondary prevention. 🧠⚖️
🔗 https://www.nejm.org/doi/full/10.1056/NEJMoa2513880
New #PaperOfTheMonth 🔍
🧠Stroke in people living with #HIV is rising & often underrecognized.
🧩A complex mix of
👉vasculopathy
👉inflammation
👉ART effects
👉and traditional risk factors is driving risk at younger ages
Read and listen here ⤵️
https://www.world-stroke-academy.org/news/the-paper-of-the-month-april-5/
