Sickle Cell Disease (II)

• Complicated by stroke in 25% before the age od 45

‐Ischemic stroke most common before the age of 20

‐Hemorrhagic stroke occurs after the age of 20

‐2/3 of patients will have recurrent stroke in 2 years from index event

• Non-atherosclerotic stenosis and occlusion of the proximal cerebral vessels
• Systemic manifestations:

‐Vaso-occlusive crises causing chest, back and extremity pain

‐Compensated hemolytic anemia